Diabetes
medication may aid weight loss, study says Published July 02, 2015.
Daily
shots of a drug developed for Type 2 diabetes helped overweight patients lose
an average of more than 12 pounds in about a year, a study published Thursday
in the New England Journal of Medicine suggests. The drug, liraglutide
(marketed as Saxenda), helped overweight and obese patients lose twice as much
weight as those on a placebo after 56 weeks. Lead study author Xavier
Pi-Sunyer, director of obesity research at Columbia University, said
liraglutide works by mimicking the effects of a hormone that makes the body
feel full. Researchers conducted a double-blind trial involving 3,731
patients who did not have Type 2 diabetes and who had a body mass index (BMI)
of at least 30, or a BMI of at least 27 if they had treated or untreated
dyslipidemia, or hypertension. Participants were randomly assigned to receive
either a once-daily injection of liraglutide in a 3 mg dose or a placebo. The
mean age of the patients was 45, and their mean weight was 233 pounds.
Liraglutide is used, along with diet and exercise, to control blood sugar
levels in adults with Type 2 diabetes. Study participants all received
counseling on lifestyle modifications and were asked to reduce their intake of
food by a small amount and increase their exercise by 150 minutes each week. The
most common side effects were mild or moderate nausea and diarrhea.
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